Publications

Publications of researchers associated with the Centre, in the area of dementia/Alzheimer’s disease, include: 

Journal Articles

2010

  1. Lui JK, Laws SM, Qiao-Xin Li, Villemagne V, Ames D, Brown B, Bush AI, DeRuyck K, Dromey J, Ellis KA, Faux NG, Fostr J, Fowler C, Gupta V, Hudson P, Laughton K, Masters CL, Pertile K, Rembach A, rimajova M, Rodrigues M, Rowe C, Rumble R, Szoeke C, Taddei K, Taddei T, Trounsen B, Ward, V, Martins RN. Plasma amyloid beta as a biomarker in Alzheimer’s disease: The AIBL Study of Ageing.  Journal of Alzheimer’s Disease Accepted 18.02.2010.
  2. Rodrigues MA, Foster JK, Verdile G, Joesbury K, Prince R, Devine A. Mehta P, Beilby J. Martins RN. Predicting memory decline as a risk factor for Alzheimer’s disease in older post-menopausal women: quod erat demonstrandum? Int. Psychogeratr. (2010) Mar: 22(2) 332-5.

2009

  1. Ian J. Martins, Tamar Berger, Matthew J. Sharman, Giuseppe Verdile, Stephanie J. Fuller and Ralph N. Martins; Cholesterol Metabolism and Transport in the Pathogenesis of Alzheimers disease, Journal of Neurochemistry, (2009)  111(6) 1275-308.
  2. Sudarsan Krishnaswamy, Giuseppe Verdile, David Groth, Limbikani Kaneyenda and Ralph N Martins; The structure and function of Alzheimers gamma secretase enzyme complex, Critical Reviews in Clinical Laboratory Sciences, 2009 46(5-6):282-301.
  3. Bourgeat P, Chetelat G, Villemagne VL, Fripp J, Raniga P, Acosta O, Szoeke C, Ourselin S, Ames D, Ellis KA, Martins RN, Masters CL, Rowe CC, Salvado O and the AIBL Research Group. Aβ burden in the temporal neocortex is related to hippocampal atrophy in non-demented elderly. Neurology, (In Press).
  4. Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho Lap, Fraswer P, Westaway D, Hyslop P StG, Martins RN, Buxbaum JD, Pasinetti GM, Dicksterin DL, Hof PR, Ehrlich ME, Gandy S. Dietry composition modulates brain mass and solubilizable A levels in a mouse model of aggressive Alsheimer’s amyloid pathology. Molecular Neurodegenration (2009) 4:40.
  5. Chen M, Martins RN, Lardelli M. complex splicing and neural expression of duplicated tau genes in Zebrafish embryos. Journal of Alzheimer’s Disease. (2009) 18(2)305-17.
  6. Hata S. Fujishige S. Araki Y. Kato N. Araseki M. Nishimura M.  Hatmann D, Saftig P, Fahrenholz, F, Taniguchi M, Katsuya U, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T.  Alcadein cleavages by amyloid B-Precursor Protein (APP) α- and γ-Secretases generate small peptides, p3-Alcs, indicating Alzheimer’s disease-related γ-secretase dysfunction. Journal of Biological Chemistry. 2009 Vol 284 No. 52, 36024-36033.
  7. Sohrabi HR, Bates KA, Rodrigues M. Taddei K, Martins G, Laws SM, Lautenschlager NT, Dhaliwal SS, Foster JK, Martins RN, The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Ee4 carriers and non-carriers? Journal of Alzheimer’s disease, (2009) 17(1):69-79.
  8. Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IA. Aβ aggregation and possible implication in Alzheimer’s disease pathogenesis.  Journal of Cellular and Molecular Medicine. (2009) 13(3)412-21.
  9. Foster JK, Verdile G, Bates KA, Martins RN, Immunization in Alzheimer’s disease: naïve hope or realistic clinical potential? Molecular Psychiatry (2009) 14:239-251
  10. Bates KA, Verdile G. Q-X Li, Ames D, Hudson P, Masters CL and Martins RN. Clearance mechanisms of Alzheimer’s amyloid-β peptide: implications for therapeutic design and diagnostic tests. Feature Review Molecular Psychiatry (2009) 14:469-486.
  11. Barron A.M., Cake M., Verdile G., and Martins RN. Ovariectomy and 17b-estradiol replacement do not alter beta amyloid levels in sheep brain. Endocrinology, (2009) 150(7):3228-36
  12. Sohrabi HR, Bates KA, Rodrigues M, Taddei K, Laws SM, Lautenschlager NT, Dhaliwal SS, Johnston ANB, Mackay-Sim A, Foster JK, Martins RN. Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals.  Journal of Alzheimer’s Disease (2009) 17(1): 135-42.
  13. Bates K, Hamid R, Sohrabi H, Rodrigues M, Beilby J, Dhaliwal SS, Taddei K, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager N. Mastaglia F, Laws S, Gandy SE, & Martins RN. Association of Cardiovascular Factors & Alzheimer’s Disease Plasma Amyloid-β Protein in Subjective Memory Complainers.  Journal of Alzheimer’s Disease  (2009)  Mar 56 E-Pub ahead of print.
  14. Taddei K, Laws SM, Verdile G, Munns S, D’Costa K, Harvey AR, Martins IJ, Hill F, Levy C, Shaw JE. & Martins RN. Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotxicity. Neurobiology of Aging (2009) E-Pub ahead of print.
  15. Nornes S, Newman M, Wells S, Verdile G, Martins RN & Lardelli M. Independent and co-opertive action of Psen2 with Psen1 in Zebrafish embryos. Esp. Cell Res (2009) Accepted June 26 (Epub ahead of print)
  16. Ellis KA, Bush AI,Darby D, De Fazio D, Foster J, Hudson P, Lauatenschlager NT, Lenzo N, Martins RN, Maruff P, Masters C, Milner A, Pike Rowe, Savage G, Szoeke C, Taddei K, Villemagne V, Woodward M, Ames D: The AIBL Reserch Group.  The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease INT Psychogeriatr. 2009 May 27:1-16 (Epub ahead of print).
  17. Drummond ES, Harvey AR, Martins RB. Androgens and Alzheimer’s disease.  Curr Opin Endocrinol Diabetes Obes. 2009 June 16 (3): 254-9 Review.
  18. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Clinical epidemiology and in-patient hospital use in the last year of life (1990-2005) of 29 884 Western Australians with dementia Journal of Alzheimer's Disease 2009; 17: 399-407.
  19. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Linkage of hospital and death records increased identification of dementia cases and death rate estimates Neuroepidemiology 2009; 32 (1): 61-69.

2008

  1. Hsien W.Chan, Tianbing Liu, Giuseppe Verdile, Glenda Bishop, Ryan J Haasl, Mark A Smith, George Perry, Ralph N Martins and Craig S Atwood. Copper Induces Apoptosis of Neuroblastoma Cells via Post-translatinal Regulation of the Expression of Bcl-2-family Proteins and the txj Mouse is a better Model of Hepatic than Brain Cu Toxicity. Int J Clin Exp Med (2008) 1:76-88.
  2. Miklossy J., and Martins RN. Chronic Inflammation and Amyloidgenesis in Alzheimer’s Disease: The emerging Role of Infection. Journal of Alzheimer’s Disease. (2008) 13(4) 357.
  3. Maczurek A, Hager K, Kenklies M, Sharman M, Martins RN, Engel J, Carlson DA, Munch G. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease.  Advanced Drug Delivery Reviews (2008) 60:1463-1470.
  4. Bates, K.A., Sohrabi, H. R., Rodrigues, M., Beilby, J., Dhaliwal, S.S., Taddei, K., Criddle A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J. K., Martins, I. J., Lautenschlager, N. T., Mastaglia, F., Laws, S. M. and Martins, R. N. “Relationship between cardiovascular disease risk factors and Alzheimer’s disease Aβ protein in subjective memory complainers”. Journal of Alzheimer’s Disease, accepted December 2008.
  5. Verdile G and Martins RN.  The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism. In Hogervorst, Henderson, Gibbs & Brinton (Eds.), Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. Cambridge University Press, Shaftesbury Road, Cambridge CB2 8RU, UK, 2008  in press
  6. Barron, A.M., Taddei, K., Verdile, G. & Martins, R.N. Time and dose dependent effects of human chorionic gonadotropin on APP processing and beta amyloid levels in the PS1M146V mouse model of Alzheimers disease. Alzheimer's and Dementia. 2008 4(4) S1:T347
  7. Bruce DG, Davis WA, Casey G, Starkstein S, Clarnette R, Almeida OA, Davis TME. Predictors of cognitive decline in older people with diabetes.  Diabetes Care 2008; 31:2103-2107.
  8. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Linkage of hospital and death records increased identification of dementia cases and death rate estimates. Neuroepidemiology 2009; 32: 61-69.
  9. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Clinical epidemiology and in-patient hospital use in the last year of life (1990-2005) of 29,884 Western Australians with dementia. Journal of Alzheimer’s Disease
  10. Rosenwax LK, McNamara B, Zilkens RR. A population-based retrospective cohort study comparing care for Western Australians with and without Alzheimer's disease in the last year of life. Health and Social Care in the Community 2008; 17 (1): 36-44.
  11. Panegyres PK, McCarthy M, Campbell A, Lenzo N, Fallon M, Thompson J. 2008. Correlative studies of structural and functional imaging in primary progressive aphasia. Am J Alzheimers Dis Other Demen. 23(2):184-91. Epub 2008 Jan 11
  12. Almeida O, Garrido G, Beer C, Lautenchlager NT, Arnolda L, Lenzo NP, Campbell A, Flicker L. 2008. Myocardial infarction is associated with regional grey matter volume loss: implications for cognitive function and behaviour. Intern Med J. 2008 Jul;38(7):599-606.
  13. Auret, K., Toye, C., Goucke, R., Kristjanson, L. J., Bruce, D., & Schug, S. (2008). Development and testing of a modified version of the Brief Pain Inventory (Cleeland, 1989) for use in residential aged care facilities. Journal of the American Geriatrics Society, 52(2), 301-306.
  14. McConigley, R., Toye, C., Goucke, R., & Kristjanson, L. J. (2008). Developing Recommendations for Implementing the Australian Pain Society’s Pain Management Strategies in Residential Aged Care. Australasian Journal on Ageing, 27, (1), 45-49.
  15. Dalton, P.D., Harvey, A.R., Oudega, M. and Plant, G.W. (2008)  Tissue engineering of the nervous system, In: Tissue Engineering. C van Blitterswijk, P Thomsen, A Lindahl, J Hubbell, D Williams, R Cancellah, J de Bruijn, J Sohier (Eds.), Academic Press Series in Biomedical Engineering, pp. 611-647.
  16. Lee, J-P., Tsai, D.J., Park, K.I., Harvey, A.R. and Snyder, E.Y. (2009)  The dynamics of long term transgene expression in engrafted neural stem cells. J Comp. Neurol., (in press Oct 2008).
  17. Foster JK, Verdile G, Bates KA, Martins RN. Immunization in Alzheimer's disease: naïve hope or realistic clinical potential? Molecular Psychiatry. 2008 Oct 28. [Epub ahead of print]
  18. Bates KA, Verdile G, Li QX, Ames D, Hudson P, Masters CL, Martins RN. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry. 2008 Sep 16. [Epub ahead of print]
  19. Wahjoepramono EJ, Wijaya LK, Taddei K, Martins G, Howard M, de Ruyck K, Bates K, Dhaliwal SS, Verdile G, Carruthers M, Martins RN. Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-beta levels. Journal of Alzheimer’s Disease 2008 Sep;15(1):129-37.
  20. Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, Miklossy J, Hallmayer J, McGeer PL, Martins RN. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation. 2008 Aug 20;5:36.
  21. Rimajova M., Lenzo N.P., Bates K.A., Campbell A., Dhaliwal S.S., McCarthy M., Rodrigues M.A., Rowe C., Foster J.K., Martins R.N. (2008) Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEε4 carriers in the Australian population. Journal of Alzheimer’s Disease. 13, 137-146.
  22. Sunram-Lea SI, Dewhurst SA, Foster JK (2008) The effect of glucose administration on the recollection and familiarity components of recognition memory. Biological Psychology, 77, 69-75.
  23. Verdile G, Yeap BB, Clarnette RM, Dhaliwal S, Burkhardt MS, Chubb SAP, De Ruyck K, Rodrigues M, Mehta PD, Foster JK, Bruce DG, Martins, RN (2008) Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men. Journal of Alzheimer’s Disease, 14, 201-208.
  24. Bruce DG, Davis WA, Casey GP, Starkstein SE, Clarnette RM, Foster JK, Almeida OP, Davis TME (2008) Predictors of cognitive impairment and dementia in older people with diabetes. Diabetologia, 51, 241-248.
  25. Rodrigues, M.A., Verdile G., Foster J.K., Hogervorst E., Joesbury K., Dhaliwal S., Corder E.H, Laws, S.M., Hone E., Prince, R., Devine A., Mehta, P., Beilby J., Atwood C.S., Martins, R.N. (2008) Gonadotropins and cognition in older women. Journal of Alzheimer’s Disease, 13, 267-274.
  26. Foster, J.K., Smith, M.A. & van Eekelen, A. (In Press) Cognitive Science of Memory: Neurochemistry is Important Too. Trends in Cognitive Sciences.
  27. De Silva R, Disanayaka S, De Zoysa N, Sanjeewanie N, Somaratne S, Foster JK, Srikanth S, Kathriarachchi S, Martins R (Accepted) Prevalence of cognitive impairment in elders' homes in Sri Lanka. International Journal of Geriatric Psychiatry.
  28. Sohrabi, Hamid R, Bates, Kristyn A., Rodrigues, Mark, Taddei, Kevin, Martins, Georgia1, Laws, Simon M, Lautenschlager, Nicola T, Dhaliwal, Satvinder S, Foster, Jonathan K, Martins, Ralph N * The relationship between memory complaints, perceived quality of  life and mental health in apolipoprotein E4 carriers and non-carriers? Journal of Alzheimer’s Disease (In Press)
  29. Sohrabi, Hamid R; Bates, Kristyn A; Rodrigues, Mark; Taddei, Kevin; Laws, Simon M; Lautenschlager, Nicola T; Dhaliwal, Satvinder S;  Johnston, Amy N.B; Mackay-Sim, Alan; Foster, Jonathan K.;  Martins, 
    Ralph N. Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer’s Disease (In Press)
  30. Foster J.K., Sohrabi H., Verdile G., and Martins R.N. (2008). Research criteria for the diagnosis of Alzheimer’s disease: genetic risk factors, blood biomarkers and olfactory dysfunction. International Psychogeriatics, 20:853-855
  31. Chan H.W., Liu T.,Verdile G, Bishop G, Haas R.J., Smith M.A., Perry G., Martins R.N. and Atwood C.S. (2008). Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the txJ Mouse is a Better Model of Hepatic than Brain Cu Toxicity. Int J Clin Exp Med, 1: 76-88.
  32. Taddei K.;Laws, S.M.,Verdile G., Munns S., D'Costa K., Harvey A.R.,;Martins I.J., Hill, F., Levy E., Shaw J.E., and Martins R.N. (2008). Novel phage peptides attenuate amyloid-beta 42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, in press, Accepted 31/3/08. [Epub ahead of print]
  33. Verdile G and Martins RN (2008). Molecular Genetics of Alzheimer’s Disease. In Wildenauer D  (ed) Molecular Biology of Neuropsychiatric Disorders  pp 231-278. Springer-Verlag, Berlin Heidelberg. (Book Chapter)
  34. Verdile G and Martins RN (2008). Alzheimer’s Disease: a Research update from WA. Women in Science Enquiry Network (WISENET ) Journal 78: 7-10
  35. Barron AM., Verdile G. and Martins RN (2008). The Role of Luteinizing Hormone in Alzheimer’s Disease. In Gonadal and nongonadal actions of Gonadotropinsn pp 275-290. Narosa Publishing House Pvt. Ltd, Dehli, India.
  36. Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging. 2008 Oct 16. [Epub ahead of print]
  37. Urosevic N, Martins RN. Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism. J Alzheimers Dis. 2008 May;13(4):421-35. Review. PMID: 18487850 [PubMed - indexed for MEDLINE]

2007

  1. Kristjanson, L. J., Walton, J., & Toye, C. (2007). Palliative Care for the Aged Care Community: An Australian Perspective. In Morse, C. (Ed). The Art of Ageing in a Global Community: Lessons from Three Nations. New York: Baywood.
  2. Nornes S, Newman M, Verdile G, Wells S, Stoick-Cooper C, Tucker B, Frederich-Sleptsova I, Martins R and Michael Lardelli. (2007). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17: 402-412
  3. Barron A, Taddei K, Verdile G, and Martins RN (2007). Human chorionic gonadotropin increases exploratory behaviour and impairs episodic memory in PS1M146V mice. Neuroscience Research 58: Supplemnet 1, S62
  4. Verdile G, Gandy SE and Martins RN. (2007) The role of presenilin and it interacting proteins in the biogenesis of Alzheimer’s beta amyloid. Neurochemical Research 32: 609-623
  5. Fuller SJ. Tan RS. Martins RN.  Androgens in the Etiology of Alzheimer’s Disease in Aging Men and Possible Therapeutic Interventions. Journal of Alzheimer’s Disease (2007) 12:129-142.
  6. McRae A, Martins RN, Fonte J, Kraftsik R, Hirt L, Miklossy J. Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: A putative marker of an ongoing inflammatory process. (2007) Apr; 42(4):355-63.
  7. Foster J.K., Sohrabi H., Verdile G., and Martins R.N.. Research criteria for the diagnosis of Alzheimer’s disease: genetic risk factors, blood biomarkers and olfactory dysfunction. International Psychogeriatics, doi:10.1017/S1041610208006807 (2007)
  8. Rodrigues, M.A., Verdile G., Foster J.K.,  Hogervorst E., Joesbury K., Dhaliwal S., Corder E.H, Laws, S.M., Hone E., Prince, R., Devine A., Mehta, P., Beilby J.,  Atwood C.S., Martins, R.N. Gonadotropins and Cognition in Older Women. Journal of Alzheimer’s Disease (2007)
  9. Rimajova M., Lenzo N.P., Bates K.A., Campbell A., Dhaliwal S.S., McCarthy M., Rodrigues M.A., Rowe C., Foster J.K., Martins R.N. Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEε4 carriers in the Australian population. Journal of Alzheimer’s Disease (2007)
  10. Verdile G, Gandy SE, Martins RN.  The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.  Neurochem Res.  2007 Apr-May; 32(4-5):609-23. Epub 2006 Aug 31. Review. PMID: 16944319
  11. Flicker L, Martins RN, Thomas J, Acres J, Taddei K, Vasikaran SD, Norman P, Jamrozik K, Almeida OP. B-vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging 2008 29:303-305.

2006

  1. Barron AM, Verdile G. Martins RN, the role of gonadotropins in Alzheimer’s disease: potential neurodegenerative mechanisms.  Endocrine (2006) Apr 29; 29(2):257-70. 
  2. Barron A, Verdile G and Martins RN. Gonadotropins: potential targets for preventative and therapeutic interventions in Alzheimer’s disease.  Future Medicine (2006) 1(2) 189-202.
  3. Martins IJ, Hone E, Foster J, Sünram-Lea S, Gnjec A, Fuller SJ, Nolan D, Gandy, SE and Martins RN. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer’s disease and cardiovascular disease.  Molecular Psychiatry (2006) 11, 721-736 (online)
  4. Barron AM, Verdile G. and Martins RN. The role of gonadotropins in Alzheimer’s disease: potential neurodegenerative mechanisms.  Endocrine (2006) (2):257-70.
  5. Bates KA, Martins RN, and Harvey AR. Oxidative stress in a rat model of chronic gliosis. Neurobiol Aging. (2006) June 22(e-publication ahead of print).
  6. Burkhardt MS, Foster JK, Clarnette RM, Chub SAP, Bruce DG, Drummond PD, Martins RN and Yeap BB. Interaction between Testosterone and Apolipoprotein E e4 Status on Cognition in Healthy Older Men. The Journal of Endocrinology & Metabolism. (2006) 91(3):1168-1172.
  7. House MJ, St Pierre TG, Foster JK, Martins RN, Clarnette R. Quantitative MR imagining R2 relaxometry in elderly participants reporting memory loss. American Journal Neuroradiology.  (2006) (2):430-9.
  8. Verdile G, Gandy SE and Martins RN. (2006) The role of presenilin and it interacting proteins in the biogenesis of Alzheimer’s beta amyloid. Neurochemical Research Aug 31 [e-publication ahead of print]
  9. Riemenschneider M, Konta L, Friedrich P, Schwarz S, Taddei K, Neff F, Padovani A, Kolsch H, Laws SM, Klopp N, Bickeboller H, Wagenpfeil S, Mueller J, Rosenberger A,  Diehl-Schmid J, Archetti S, Lautenschlager N, Borroni B, Muller U, Illig T, Heun R, Egensperger R, Schlegel J, Forstl H, Martins RN, Geman Sib-Pair Study Group, Kurz A. A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer’s disease. Human Molecular Genetics (2006) (15) 2446-2456. 
  10. Barron AM, Fuller SJ, Verdile G, Martins RN. Reproductive hormones modulate oxidative Stress in Alzheimer’s disease. Antioxid. Redox signal. (2006) Nov 8(11-12):2047-2059
  11.  Pickering-Brown SM, Baker M, Gass J, Boeve BF, Loy CT, Brooks WS, Mackenzie IRA, Martins RN, Krok JBJ, Halliday GM, Kril J, Schofield PR, Mann DMA, Hutton M. Mutations in progranulin ecxplain atypical phenotyres with variants in MAPT. Brain (2006) 129: 3124-3126. 
  12. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins RN, Reiss K, Darbvinian N, Darekar P, Mihaly L, Khalili K. Beta-amyloid deposition and Alzheimer’s type changes induced by Correlia spirochetes. Neurobiology of Aging 2006) 27: 228-236. 
  13. Flicker L, Martins RN, Thomas J, Psych JA, Taddei K, Vasikaran SD, Norman P, Jamrozik K, Almeida OP. B-vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging (2006) Nov. 17 [Epub ahead of print] 
  14. Butterfield, DA, Gnjec A, Poon HF, Castegna A, Pierce WM, Klein JB, Martins RN.  Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer’s disease: An Initial assessment. Journal of Alzheimer’s Disease. 2006 10(4):391-7. 
  15. McRae A, Martins RN, Fonte J, Kraftsik R, Hirt L, Miklossy J. Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: A putative marker of an ongoing inflammatory process. Exp. Gerontology (2006) Nov. 29 [EPub ahead of print]
  16. Bradley, C.K., Takano, E.A., Hall, M.A., Göthert, J.R., Harvey, A.R., Begley, C.G. and van Eekelan, J.A.M. (2006)  The essential hematopoietic transcription factor SCL is also critical for neuronal development. Eur. J. Neurosci., 23:1677-1689.
  17. Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W. and Cui, Q. (2006)  Gene therapy and transplantation in CNS repair: the visual system.  Prog. Retin. Eye Res., 25: 449-489.
  18. Harvey, A.R. and Plant, G.W. (2006) Olfactory ensheathing glia and spinal cord injury: basic mechanisms to transplantation. Future Neurol., 1: 453-463.
  19.  Leaver, S.G., Cui, Q, Bernard, O. and Harvey, A.R. (2006) Cooperative effects of Bcl-2 and AAV-mediated expression of CNTF on retinal ganglion cell survival and axonal regeneration in adult transgenic mice.  Eur. J. Neurosci., 24: 3323-3332.
  20. Leaver, S.G., Cui, Q., Plant, G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J. and Harvey, A.R. (2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells.  Gene Ther., 13: 1328-1341
  21. Leaver, S.G., Harvey, A.R. and Plant, G.W. (2006) Adult olfactory ensheathing glia promote the regeneration of adult retinal ganglion cells axons in vitro.  Glia, 53: 467-476.
  22. Spalding, K.L., Cui, Q., Dharmarajan, A.M. and Harvey, A.R. (2006) Injury-induced retinal ganglion cell loss in the neonatal rat retina.  In: Retinal Degenerative Diseases, Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail (Eds), Springer, New York, NY,  Adv. Exp. Med. Biol., 572: 447-451.
  23. Taaffe DR, Galvão, D.A., Sharman JE Coombes JF. Reduced central blood pressure in older adults following progressive resistance training. Journal of Human Hypertension. 21:96-98, 2007.
  24. Galvão D.A., Nosaka K, Taaffe DR, Spry N, Kristjanson LJ, McGuigan M.R. Suzuki K, Yamaya K., & Newton R.U. Resistance training and reduction of treatment side-effects in prostate cancer patients. Medicine and Science in Sports and Exercise. 2045-2052, 2006.
  25. Galvão, D.A., Newton R.U. and Taaffe D.R. Does sex affect the muscle strength and regional lean tissue mass response to resistance training in older adults? International Journal of Sport and Health Science. 4:36-43, 2006.

Book Chapter

  1. Barron AM., Verdile G. and Martins RN (2008). The Role of Luteinizing Hormone in Alzheimer’s Disease. In Gonadal and nongonadal actions of Gonadotropinsn pp 275-290. Narosa Publishing House Pvt. Ltd, Delhi, India.
  2. Kristjanson, L. J., Walton, J., & Toye, C. (2007). Palliative Care for the Aged Care Community: An Australian Perspective. In Morse, C. (Ed). The Art of Ageing in a Global Community: Lessons from Three Nations. New York: Baywood.

Conference Presentations - Published Abstracts

  1. The AIBL Study: Baseline data from a multicentre, prospective longitudinal study of ageing in 1100 volunteers.  Ames D, Rowe C, Masters C, Martins R, Szoeke C, Hudson P, Milner A, Ellis K.  14th International Psychogeriatric Association  International Congress 1-5 September 2009 Montreal Canada. Vol 21 Supp 2 S59-S60.
  2. Establishment of the plasma biomarkers for the pre-symptomatic detection of AD: Australia Imaging, Biomarker and Lifestyle (AIBL) Flagship Study of Ageing. Martins RN, Gupta V, Lui J, Foster J, Taddei K, Taddei T, Brown B, Ward V, Rodrigues M, .Masters C.14th International Psychogeriatric Association  International Congress 1-5 September 2009 Montreal Canada. Vol 21 Supp 2 S59-S60.
  3. Amyloid-β and its relevance to the detection of Alzheimer’s disease in blood plasma: Findings from the first phase of the Australian Imaging, Biomarker and Lifestyle (AIBL) Flagship study of ageing.  De Ruyck, K, Gupta V, Qiao-Xin Li, Taddei K, Foster J. Taddei T, Brown B, Ward C, Rodrigues M, Ellis K, Rowe C, Villemagne V, Hudson P, Masters C, Martins, RN, Ames D.  ICAD Vienna Austria July 11-16 2009.
  4. Effect of cortical placement of luteinizing Hormone on Aβ metabolism in guinea pigs.  Wijaya LK, Wahjoepramono EJ, Taddei K, Martins G, Howard M, Bates KA, Dhaliwal SS, Verdile G, Martins RN, ICAD Vienna Austria July 11-16 2009.
  5. The association between APOE Levels and Alzheimer’s Disease: Australian Imaging, Biomarker and Lifestyle (AIBL) Flagship Study of Ageing.  Martins RN et al. ICAD Vienna Austria July 11-16 2009.
  6. Vidovich M., Almeida O., 13th Alzheimer’s Australia National Conference (Adelaide) June 2009
  7. Establishment of the plasma biomarkers for the pre-symptomatic detection of AD: Australia Imaging, Biomarker and Lifestyle (AIBL) Flagship Study of Ageing. Martins RN, Gupta V, Lui J, Foster J, Taddei K, Taddei T, Brown B, Ward V, Rodrigues M, .Masters C. 24th Conference of Alzheimer’s Disease International Singapore 25-28 March 2009.
  8. The Role of Physical Activity on Blood Bio-Markers Related to Alzheimers Disease Brown BM, Peiffer JJ, Taddei K, Lui J, Taddei T, Ward VK, Rodrigues MA, Rimajova M, Foster JK, Ellis K, Masters C, Ames D, Hudson P, Rowe C, Martins RN 9th International  AD/PD Conference Prague March 2009
  9. The role of lean body mass on cognition and blood biomarkers in a healthy control population: a component of the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study Peiffer JJ, Brown BM, Taddei K, Lui J, Taddei T, Ward VK, Rodrigues MA, Rimajova M, Foster JK, Ellis K, Masters C, Ames D, Hudson P, Rowe C, Martins RN. 9th International AD/PD Conference Prague March 2009
  10. The AIBL Study: Baseline data from a multicentre, prospective longitudinal study of ageing in 1100 volunteers. Ellis K, Rowe C, Masters C, Martins RN, Hudson P, Milner A, Bevege L, Ames D. 9th International  AD/PD Conference Prague March 2009
  11. Zilkens RR. Alzheimer's disease and dementia in Western Australia: Population based estimates of utilisation of health care services and outcome Alzheimer's Australia WA. Wembley, Western Australia., March 2009. (Invited Presentation)
  12. DG Bruce, WA Davis, GP Casey, RM Clarnette, SG Brown, IG Jacobs, OP Almeida, TM Davis. Cognitive impairment and hypoglycaemia in older patients with diabetes: Cause or effect? VAS-Cog Conference.  Platform presentation. Singapore January 2009
  13. Peiffer J.J., Galvao D., Turner D., Almeida O., Martins R., and Newton R.U. Go to a clinic or stay at home? Examining a 6-month home- and clinic-based resistance training program in healthy older adults. 2008 Vario Health Conference: Physical and Mental Wellness Integrated Approaches to Health. Perth, Western Australia 1st and 2nd December, 2008.
  14. Vidovich M., Almeida O.,7th National Conference of Emerging Researchers Australia (Fremantle) November 2008
  15. Ellis KA, Rowe C, Masters CL Martins RN, Hudson P, Milner A, Bevege L, Ames D.(2008) Baseline Data from the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing.  DCRC Sept 2008 Sydney.
  16. Bates KA, Sohrabi H, Rodrigues M, De Ruyck K, Beilby J, Dhaliwal SS, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager N, Mastaglia FL, Laws SM, Gandy SE, Martins RN, Relationship between cardiovascular disease risk factors and Alzheimer’s disease ABeta protein in subjective memory complainers. ICAD July/August 2008.
  17. Sohrabi H, Bates KA, Rodrigues M, Taddei K, Laws S, Lautenschlager N, Dhaliwal S, Johnston A, MacKay-Sim A, Foster JK, Martins RN. Frequency of forgetting is associated with olfactory functions in healthy, community-dwelling elderly.  ICAD July/August 2008.
  18. Martins RN, Sharman M, Taddei K, Martins I, Hone E, Berger T. Isoform-specific effects of Apoe on beta-amyloid clearance of beta and lipid metabolism. ICAD (Poster & Oral presentation) July/August 2008.
  19. Ellis KA, Rowe, C, Masters CL, Martins RN, Hudson P, Milner A, Bevege L, Savage G, Ames, D. Baseline data from a multicentre, prospective longitudinal study of ageing in 100 volunteers (The AIBL Study). ICAD July/August 2008.
  20. DG Bruce, WA Davis, GP Casey, SE Starkstein, OP Almeida, TM Davis. Cognitive decline in diabetes: Impact of microalbuminuria and renin-angiotensin system inhibitors.  Int Conf Alzheimer’s Disease Chicago July 2008.
  21. Barron, A.M., Taddei, K., Verdile, G. & Martins, R.N. (2008). Human chorionic gonadotropin elevates beta amyloid levels in a mouse model of Alzheimers disease. The Endocrine Society’s 90th Annual Meeting. 13-18 June, 2008 San Francisco, California, USA.
  22. Gibbs Z., R.U. Newton, D.A. Galvão, D. Turner and K. Smith. Resistance training in older adults: A comparison between group-and home-based exercise training for improvements in functional performance, muscle function, and balance. Proceedings of the 3rd Australian Association for Exercise and Sports Science Conference and the 5th Sports Dieticians Australia Update: From Research to Practice. Page 130. Melbourne Australia 27th – 30th March 2008.
  23. Anna Barron, K.Taddei, K.Croft, T.Mori, G.Verdile and  R.Martins; Time and dose dependent effects of ovariectomy and human chorionic gonadotropin treatment on beta amyloid and F2-isoprostane levels in the PS1M146V knock-in mouse model of Alzheimer’s disease. Conference abstract: International Conference on Alzheimer's Disease 2008, Chicago USA.
  24. Alzheimer’s Association International Conference on Alzheimer’s Disease 2008, Chicago, USA. Title of paper:  “The Australian biomarker, imaging and lifestyle (ABIL) study: Preliminary PIB results” Ellis KA, Villemagne VL, Ames D, Lenzo N, Pike KE, O'Keefe G, Tochon-Danguy H, Price R, Jones G, Rimajova M, Bourgeat P, Raniga P, Fripp J, Salvado O, Martins R, Masters CL, Rowe CC.
  25. Poster Presentation: International Brain Research Organisation (IBRO), world congress of Neuroscience, 2007, Melbourne, Australia. Giuseppe Verdile, Roger Clarnette, Satvinder Dhaliwal, Karl De Ruyck Mark Rodrigues, Melanie Burkhardt , Jonathan K. Foster, Bu B.Yeap, David G. Bruce, Ralph N. Martins; Luteinizing hormone is positively correlated with plasma beta amyloid levels in cognitively normal elderly men”
  26. Barron A, Taddei K, Verdile G, and Martins RN (2007). Human chorionic gonadotropin increases exploratory behaviour and impairs episodic memory in PS1M146V mice. Conference abstract: The 31st Annual Meeting of the Japan Neuroscience Society, 2007, Pacifico Yokohama
  27. Invited symposium speaker, The 24th Symposium of Western Australian Neuroscience, Perth, Australia Giuseppe Verdile, Ralph Martins; The Genetics of Alzheimer’s Disease”
  28. Toye, C., Kristjanson, L. J., Auret, K., Bruce., D., Schug, S., Young, J., & Popescu., A. (2007). Refining a pain assessment self report tool for use in residential aged care. The 40th National Conference of the Australian Association of Gerontology, Adelaide, Australia Journal on Ageing, 26 (Supp. 1), A40.
  29. Toye, C. (2007). Kristjanson, L. J.,Goucke, R., & McConigley, R.  The Australian Pain Society's Residential Aged Care Pain Management Strategies: Development of guidelines, a toolkit, and recommendations for implementation. Oral presentation at the Western Australian Palliative Care Conference, Fremantle, Western Australia.
  30. Toye, C., Popescus, A., Drake, J., & Lester, L. (2007). Effectiveness of dementia specific carer education delivered throughout Western Australia: Early findings. Poster presentation at the Alzheimer’s Australia National Conference in Perth, WA.
  31. Toye, C. (July, 2007). A palliative approach for people who have dementia. Invited presentation for the Western Australian Dementia Training Study Centre.
  32. Toye, C. (June, 2007). Pain management in aged care. Invited presentation at Aegis Care Seminar, Perth, Western Australia.
  33. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Record linkage of hospital and death data increased identification of dementia cases and death rate estimates. (Poster). 41st Australian Association of Gerontology National Conference. Fremantle, Western Australia., November 2008.
  34. Zilkens RR, Spilsbury K, Bruce DG, Semmens JB. Hospitalization trends in the last year of life in dementia. 5th Health Services and Policy Research Conference. Auckland, New Zealand.
  35. ANZSNM 37th Annual Scientific Meeting, Adelaide, April 2007. Title of talk: “SPECT and PET brain imaging”
  36. International Brain Research Organisation Scientific Meeting, Melbourne, July 2007. Rimajova M, Wu J, Lenzo NP, Campbell A, Bates KA, Foster JK, Martins RN. Title of paper: Altered FDG PET in Apolipoprotein E-e4 carriers with Subjective Memory Complaint”
  37. Cambridge In vitro and In vivo Molecular Imaging Meeting, San Diego Nov 2007. Rimajova M, Wu J, Lenzo NP, Campbell A, Bates KA, Foster JK, Martins RN. Title of paper: “Altered FDG PET in Apolipoprotein E-e4 carriers with Subjective Memory Complaint”
  38. 36th ANZSNM Annual Scientific Meeting, Perth, Australia, May 2006. Lenzo NP. Title of papers:
    1. “Subjective memory complaint accompanies cerebral glucose metabolic changes in Apolipoprotein E-e4 gene carriers: Preliminary results”
    2. “HMPAO SPECT, FDG PET and anatomical imaging in patients with Primary Progressive Aphasia”
  39. Annual Mid-Year Meeting of the International Neuropsychological Society, Zurich, Switzerland, July 2006. Title of paper: “Subjective memory complaint accompanies cerebral glucose metabolic changes in Apolipoprotein E-e4 gene carriers”
  40. Toye, C., Kristjanson, L. J., Auret, K., Bruce., D., Schug, S., Young, J., & Popescu., A. (2007). Refining a pain assessment self report tool for use in residential aged care. The 40th National Conference of the Australian Association of Gerontology, Adelaide, Australia Journal on Ageing, 26 (Supp. 1), A40.
  41. Robinson, A., Abbey, J., Barnes, L., Toye, C., & Abbey, B. (2007). Best practice for undergraduate nursing students in aged care clinical placements. The 40th National Conference of the Australian Association of Gerontology, Adelaide, Australia Journal on Ageing, 26 (Supp. 1), A33.
  42. Abstract: Zilkens RR, Spilsbury K, Bruce D, Semmens. Hospitalization trends in the last year of life in dementia.  5th Health Services & Policy Research Conference, Auckland, New Zealand, December 2007.
  43. Oral and Poster presentation: Rimajova M, Lenzo N.P and Martins R.N. Altered FDG-PET in Apolipoprotein E4 carriers with Subjective Memory Complaint. In Vivo Molecular Imaging Conference, San Diego, US, November 2007
  44. Androgens in Health and Disease – Fifth International Conference  The Royal Society of Medicine, London.  The Diagnosis and Treatment of Androgen Deficiency. March 2007.  Alzheimer’s Ab is differential regulated by Testosterone and Gonadotropins.  EJ Wahjoepramono, L.K. Wijaya, A Barron, K Taddei, G Martins, M Howard, K. deRuyck, K. Bates, SS Dhaliwal, G. Verdile, M Carruthers, RN Martins.
  45. Expert Meeting Hormones, Cognition and Dementia. Loughborough UK. March 2007. Testosterone Lowers Ab levels in both Plasma and Cerebrospinal Fluid. .  EJ Wahjoepramono, L.K. Wijaya, A Barron, K Taddei, G Martins, M Howard, K. deRuyck, K. Bates, SS Dhaliwal, G. Verdile, M Carruthers, RN Martins.
  46. Androgens in Health and Disease – Fifth International Conference The Royal Society of Medicine, London.  The Diagnosis and Treatment of Androgen Deficiency. March 2007. Serum levels of Luteinizing hormone are positively correlated with plasma beta amyloid levels in cognitively normal elderly men.  G. Verdile, Bu B.Yeap, RM. Clarnette, S Dhaliwal, MS. Burkhardt, SAP. Chubb, K. De Ruyck, M.  Rodrigues, PD. Mehta, JK. Foster, D. Bruce, RN. Martins.
  47. Relationship between cardiovascular disease risk factors and Alzheimer’s Aβ protein in subjective memory complainers. Bates, K.A., Sohrabi, H., Rodrigues, M., De Ruyk, K., Martins, G., Dhaliwal, S., Beilby, J. and Martins, R.N. (Australia) IBRO July 07
  48. The effect of a high-cholesterol diet on Alzheimer’s disease Beta-Amyloid protein in the guinea pig Sharman, M.J., Taddei, K., Bates, K.A., De Ruyck, K., Howard, M., Verdile, G., Mehta, P. and Martins, R.N. (Australia and USA) IBRO July 07
  49. Serum levels of luteinizing hormone are positively correlated with plasma beta amyloid levels in cognitively normal elderly men. Verdile, G., Clamette, R., Dahliwal, S., De Ruyck, K., Burkhardt, M., Yeap, B.B., Bruce, D.G. and Martins, R.N. (Australia) IBRO July 07
  50. The effect of 17β-estradiol replacement on Alzheimer’s disease related neurodegenerative changes in a sheep model of menopause Barron, A.M., Verdile, G., Cake, M. and Martins, R.N. (Australia)  IBRO July 07
  51. Altered FDG-PET in apolipoprotein Eε4 carriers with subjective memory complaint. Lenzo N.P., Rimajova M., Wu J.S., Campbell A., Bates K.A., Foster J.K., and Martins R.N. (Melbourne, Australia) IBRO July 07
  52. Truncated presenilin proteins inhibit normal presenilin function Nornes, S., Newman, M., Martins, R. and Lardelli, M. (Australia) IBRO July 07
  53. Prevalence of cognitive impairment of elderly people living in care homes in Sri Lanka De Zoysa, H.G.N.D., Sanjeewanie, S.A.N., Makawita, M.A.P., De Silva, K.R.D., Foster, J.K., Kathriarachchi, S.T. and Martins, R.N. (Sri Lanka and Australia)  IBRO July 07
  54. Association of BAT1-22 and TNFA -850 alleles with Alzheimer’s disease Gnjec, A., D’Costa, K.J., Laws, S.M., Broe, G.A., Price, P., Hallmayer, J., McGeer, P. and Martins, R.N. (Australia, Canada)  IBRO July 07
  55. Testosterone lowers beta amyloid levels in both plasma and cerebrospinal fluid.  Martins RN, Wahjoepramono EJ, Wijaya LK, Taddei K, Martins G, Howard, M, De Ruyck K, Bates KA, Dhaliwal SS. Verdile G, Carruthers M. Alzheimer’s Conference in Washington USA 2007
  56. Improving cardio vascular health results in lower levels of the Alzheimer’s beta-amyloid protein. Bates KA, Rodrigues M, Sohrabi H, Martins, G, Paton A, Taddei K, Criddle A, Wraith M, Mehta P, Bilby J, Dhaliwal, Foster J, Gandy S, and Martins RN, 2007 Alzheimer’s Australia Conference
  57. The potential of quantitative MRI relaxometry for assessing and monitoring brain iron changes associated with Alzheimer’s disease. House MJ, Foster JK, St Pierre TG, Martins RN, and Clarnette R. 2007 Alzheimer’s Australia Conference
  58. Novel Phage peptides as selective inhibitors of human beta amyloid toxicity: in vitro and in vivo studies. Martins RN, Taddei K, Laws, SM, D’Costa K., Hill F., Bates K., Howard M., Sharman M, Martins IJ, Shaw J, Harvey AR. Alzheimer’s Association Prevention of Dementia Washington USA & IBRO Melbourne 2007
  59. Genetic factors in androgen deficiency and Alzheimer’s disease. Martins RN.  Fifth International Conference, The diagnosis and Treatment of Androgen Deficiency – The Royal Society of Medicine, London.
  60. ApoE isoforms and levels modulate beta-amyloid metabolism in vitro and in vivo. 2007 Martins RN, Sharman MJ, Taddei K., Urosevic N, Martins IJ, & Maddahi M.
  61. Research opportunities in Alzheimer’s disease. Martins RN 2007. Alzheimer’s and Related Disorders Association of Kerala, India.
  62. Role of gonadotropins in cell culture and the role of testosterone metabolism related genetics.  Martins RN 2007. Expert Meeting: Hormones, Cognitive Function & Dementia - United Kingdom.
  63. Therapeutic approaches to Alzheimer’s disease. 1007 National Institute of Mental Health and Neurosciences – Bangalore, India. Martins RN
  64. Barron A, Taddei K, Verdile G, and Martins RN (2007). Human chorionic gonadotropin increases exploratory behaviour and impairs episodic memory in PS1M146V mice. Neuroscience Research 58: Supplement 1, S62